by Tina Hesman Saey
Malaria parasites (shown in blue infecting a red blood cell) can become resistant to an antimalarial drug. But the parasites can’t pass the resistance on to their offspring, a new study has found.
NIAID/Flickr (CC BY 2.0)
Malaria parasites may build up a genetic tolerance to an antimalarial drug, but they can’t spread that resistance to future generations, researchers report in the April 15 Science.
Malaria parasites can develop mutations in the cytochrome b gene that make them resistant to a drug called atovaquone, an ingredient in the antimalarial medication Malarone. Those parasites can reproduce in human or animal hosts, but the offspring have developmental defects and die in the mosquito portion of their life cycle, Christopher D. Goodman of the University of Melbourne and colleagues discovered.
The researchers tried to transmit a drug-resistant form of malaria to mice 44 times, involving 750 mosquito bites. Only one attempt succeeded, and that parasite couldn’t spread further even after seven attempts, Goodman and colleagues found.
Cytochrome b is needed for energy generation by mitochondria. Because mitochondria are inherited from the mother, even breeding with parasites that don’t have cytochrome b mutations won’t help the parasite escape its fate. The findings suggest that other antimalarial medications that target maternally inherited organelles in the parasite may also have limited drug resistance.
Apr 16, 2016
Malaria parasite doesn’t pass drug immunity to its offspring
Subscribe to:
Post Comments
(
Atom
)
Labels
Giveaway
(
3088
)
Excerpt
(
1336
)
blog tour
(
942
)
Book Blitz
(
864
)
Cover Reveal
(
543
)
Guest post
(
518
)
Teaser
(
347
)
Book blast
(
283
)
Interview
(
260
)
Culture
(
245
)
Books
(
242
)
Trailer
(
228
)
freebie
(
227
)
Art
(
226
)
Funny
(
225
)
History
(
219
)
Promotion
(
207
)
Science
(
202
)
Articles
(
181
)
free kindle
(
145
)
Literature
(
142
)
Release Day
(
131
)
Review
(
120
)
Photography
(
115
)
nature
(
113
)
kindle
(
112
)
Gender
(
105
)
Book tour
(
90
)
Authors
(
89
)
myth
(
77
)
new release
(
77
)
Coffee
(
76
)
newsletter
(
71
)
Children
(
70
)
Music
(
66
)
box set
(
60
)
Archaeological
(
59
)
illustration
(
56
)
food
(
50
)
spotlight
(
50
)
PLAYLIST
(
49
)
social
(
48
)
0.99 sale
(
46
)
YA
(
45
)
contest
(
43
)
fantasy
(
43
)
Mythology
(
42
)
Grand Finale
(
41
)
sale
(
39
)
blog hop
(
37
)
words
(
37
)
Poetry
(
35
)
artist
(
34
)
Characters interviews
(
32
)
Game
(
32
)
syfy
(
32
)
language
(
30
)
quotes
(
30
)
recipe
(
30
)
Release Party
(
29
)
Expert
(
27
)
ads
(
21
)
mystery
(
21
)
Photos
(
20
)
reading
(
20
)
Romance
(
19
)
Animals
(
18
)
Design
(
18
)
Education
(
18
)
Street Photography
(
18
)
book highlight
(
18
)
facts
(
18
)
comics
(
17
)
health
(
17
)
writing
(
17
)
Folklore
(
16
)
Holidays
(
16
)
Movies
(
16
)
poem
(
15
)
Biology
(
13
)
top 10
(
13
)
Book release
(
12
)
Maps
(
12
)
covers
(
12
)
Book trailers
(
11
)
Cash Giveaway
(
11
)
Giveaways
(
11
)
Twitter Blast
(
11
)
Valentine
(
11
)
Friday revel
(
10
)
Libraries
(
10
)
Paranormal
(
10
)
Release blitz
(
10
)
agriculture
(
10
)
events
(
10
)
sport
(
10
)
Characters cast
(
9
)
Publishing
(
9
)
Sneak Peek
(
9
)
dream cast
(
9
)
work
(
9
)
BOOK SIGNING
(
8
)
Steam-punk
(
8
)
astronomy
(
8
)
interviews
(
8
)
plants
(
8
)
technology
(
8
)
Free Book
(
7
)
Halloween
(
7
)
NA
(
7
)
Thanks Giving
(
7
)
blog
(
7
)
blog blast
(
7
)
economy
(
7
)
letters
(
7
)
street art
(
7
)
Christmas
(
6
)
Contemporary Romance
(
6
)
Genetic
(
6
)
Goodreads giveaway
(
6
)
This and That
(
6
)
YA RELEASES
(
6
)
news
(
6
)
short story
(
6
)
writing tools
(
6
)
Amazon.
(
5
)
Audio
(
5
)
Philosophy
(
5
)
Spring
(
5
)
YA Fantasy
(
5
)
hosting
(
5
)
jobs
(
5
)
mother day
(
5
)
top 5
(
5
)
Black Friday
(
4
)
BookRave
(
4
)
Fun Facts
(
4
)
Grammar
(
4
)
Song
(
4
)
Sunday Read Recommendation
(
4
)
Weather
(
4
)
Web
(
4
)
cakes
(
4
)
deals
(
4
)
evolution
(
4
)
gift card
(
4
)
horror
(
4
)
lol
(
4
)
photographer
(
4
)
soundtrack
(
4
)
studies
(
4
)
video
(
4
)
Architecture
(
3
)
Book Swapping
(
3
)
Book tor
(
3
)
Cartoon
(
3
)
Characters
(
3
)
Computing
(
3
)
Dance
(
3
)
Easter
(
3
)
Erotica
(
3
)
Indian
(
3
)
Kindle Fire HDx Giveaway
(
3
)
St. Patrick's day
(
3
)
Suspense
(
3
)
TV series
(
3
)
Thriller
(
3
)
Translation
(
3
)
bookstore
(
3
)
chapters
(
3
)
chemistry
(
3
)
contemporary
(
3
)
ecology
(
3
)
fall
(
3
)
film director
(
3
)
guest review
(
3
)
hope
(
3
)
icon
(
3
)
launch day
(
3
)
math
(
3
)
story
(
3
)
summer
(
3
)
syfi
(
3
)
urban
(
3
)
winter
(
3
)
10 Fun Facts
(
2
)
10 things
(
2
)
4th of july
(
2
)
Adventure
(
2
)
Audiobook
(
2
)
Awards
(
2
)
Blogger Appreciation
(
2
)
Book reveling
(
2
)
Bookstores
(
2
)
Characters bio
(
2
)
Clean Sweep
(
2
)
Cover wars
(
2
)
Crime
(
2
)
Debut Author Challenge
(
2
)
Dystopian
(
2
)
Family
(
2
)
Free Shipping
(
2
)
Fun
(
2
)
Gifts
(
2
)
Graphs. STAT
(
2
)
Hop International
(
2
)
Introduction
(
2
)
Literature awards
(
2
)
Nostalgic
(
2
)
Ocean
(
2
)
Psychological
(
2
)
Psychological Thriller
(
2
)
Reading Contest
(
2
)
Release week
(
2
)
Selfies
(
2
)
Summer Reading
(
2
)
Summery of the year
(
2
)
Tablets
(
2
)
Tea
(
2
)
Titles
(
2
)
add
(
2
)
art Articles
(
2
)
birds
(
2
)
book bash
(
2
)
book contest
(
2
)
bread
(
2
)
cell & molecular biology
(
2
)
children’s literature
(
2
)
climate change
(
2
)
codes
(
2
)
discussion
(
2
)
dragons
(
2
)
ebooks
(
2
)
epic
(
2
)
extreme
(
2
)
facebook
(
2
)
facebook Blast
(
2
)
games & gadgets. test
(
2
)
ilustration
(
2
)
immunology
(
2
)
incredible
(
2
)
internet
(
2
)
labels
(
2
)
lists
(
2
)
lunch blitz
(
2
)
martial
(
2
)
min-interview
(
2
)
monsters
(
2
)
physics
(
2
)
poets
(
2
)
sea
(
2
)
tips
(
2
)
tv
(
2
)
water
(
2
)
wolf
(
2
)
5 Fun Facts
(
1
)
5 Rapid Fire Round
(
1
)
A vote
(
1
)
Action
(
1
)
Adult
(
1
)
Adult Historical Fantasy
(
1
)
Adult fiction
(
1
)
African-American Lit
(
1
)
Amazing
(
1
)
Amazon
(
1
)
Amazon.Tech
(
1
)
Announcement
(
1
)
Apology
(
1
)
April
(
1
)
Atlit Yam
(
1
)
B-day
(
1
)
Badass heroes
(
1
)
Baking
(
1
)
Bibliophile
(
1
)
Black & White
(
1
)
Blogoversary
(
1
)
Book Hop
(
1
)
Bookfest
(
1
)
Booklikes
(
1
)
Bravery
(
1
)
Bundles
(
1
)
Catalog
(
1
)
Concepts
(
1
)
Critique
(
1
)
Cut Scene
(
1
)
DVD
(
1
)
Did you know
(
1
)
Discovery
(
1
)
Disney
(
1
)
Donation Campaign
(
1
)
Earth Day
(
1
)
Etymology
(
1
)
Extravaganza
(
1
)
FAQ
(
1
)
Falafel Day
(
1
)
Favorite Reads
(
1
)
Folklure
(
1
)
Gadgets
(
1
)
Garden
(
1
)
Geography
(
1
)
Greating
(
1
)
Happy New Year. greatings
(
1
)
Heroes
(
1
)
High-Rise Buildings
(
1
)
Highlights
(
1
)
Holocaust
(
1
)
Infographic
(
1
)
Inspiration
(
1
)
International
(
1
)
Japan
(
1
)
Jazz
(
1
)
Kindness
(
1
)
Linguists
(
1
)
Literary Fiction
(
1
)
Maleficent
(
1
)
Meet the author
(
1
)
Misconceptions
(
1
)
Multicultural
(
1
)
New Adult
(
1
)
New Adult fiction
(
1
)
New Series Releases
(
1
)
New Year
(
1
)
Offers
(
1
)
PRE-RELEASE
(
1
)
Parental
(
1
)
Passover
(
1
)
Personal message
(
1
)
Picture Revision
(
1
)
Piracy
(
1
)
Pirates
(
1
)
Preview
(
1
)
Print Design
(
1
)
Psychology
(
1
)
QA
(
1
)
Query Contest
(
1
)
Quet
(
1
)
Quiz
(
1
)
Quize
(
1
)
Random Facts
(
1
)
Rapid Fire Round
(
1
)
Recommends
(
1
)
References
(
1
)
Religion
(
1
)
Reveal
(
1
)
Rhymes
(
1
)
Romantic Suspense
(
1
)
Scavenger Hunt
(
1
)
Scots
(
1
)
Sleeping Beauty
(
1
)
Sparkiversary
(
1
)
Target
(
1
)
Tax day
(
1
)
Tour
(
1
)
Tour Highlight
(
1
)
Tourney
(
1
)
Trivia
(
1
)
Typography
(
1
)
Unbelievable
(
1
)
Urban Fantasy
(
1
)
Vintage
(
1
)
Virtual Book Tour
(
1
)
Visa
(
1
)
WWII
(
1
)
Waiting on Wednesday
(
1
)
Western Historical Romance
(
1
)
What I'm reading
(
1
)
Women
(
1
)
Women’s Fiction
(
1
)
Women’s Lit
(
1
)
YA nonfiction
(
1
)
academic
(
1
)
alternative medical
(
1
)
angry robot
(
1
)
anima
(
1
)
author blog
(
1
)
available
(
1
)
book hunt
(
1
)
book industry
(
1
)
book sketch
(
1
)
book swag
(
1
)
brain
(
1
)
calligraphy
(
1
)
ceremony
(
1
)
challenge
(
1
)
clips
(
1
)
clocks
(
1
)
confidence
(
1
)
convention
(
1
)
crazy
(
1
)
creative
(
1
)
cupping
(
1
)
daimonds
(
1
)
diet
(
1
)
digital copy
(
1
)
discount
(
1
)
drugs
(
1
)
east
(
1
)
editing
(
1
)
essays
(
1
)
fairy tales
(
1
)
fashion
(
1
)
fiction
(
1
)
fool day
(
1
)
genre
(
1
)
gift
(
1
)
global warming
(
1
)
gov
(
1
)
green
(
1
)
greeting
(
1
)
guns
(
1
)
harvest
(
1
)
help
(
1
)
ideas
(
1
)
indi
(
1
)
infectious disease
(
1
)
info
(
1
)
insects
(
1
)
intro for audio
(
1
)
introducing
(
1
)
labor day
(
1
)
lego
(
1
)
make up
(
1
)
manga
(
1
)
meaning
(
1
)
message
(
1
)
money
(
1
)
monthly
(
1
)
mystical
(
1
)
names
(
1
)
names.culture
(
1
)
new cover
(
1
)
note
(
1
)
olympic
(
1
)
organic
(
1
)
out takes
(
1
)
outage
(
1
)
packing
(
1
)
palentology
(
1
)
party
(
1
)
pepco
(
1
)
physiology
(
1
)
pk
(
1
)
protein
(
1
)
protein foldingץ
(
1
)
protest
(
1
)
public transportation
(
1
)
pulp fiction
(
1
)
rare
(
1
)
recommendation
(
1
)
rescued
(
1
)
retail
(
1
)
reveal tour
(
1
)
revel party
(
1
)
shopping
(
1
)
solutions
(
1
)
songs tracks
(
1
)
support
(
1
)
surfing
(
1
)
survival
(
1
)
swords
(
1
)
tags
(
1
)
theater
(
1
)
title reveal
(
1
)
top 12
(
1
)
trees
(
1
)
update
(
1
)
visual
(
1
)
winner of giveaway
(
1
)
wo
(
1
)
No comments :
Post a Comment